Name: Scientific Overview of Adipose Tissue From the AutoPose™ System
Uploaded: 2025-07-31T00:00:00Z
Channel: Arthrex
Description: Lisa A. Fortier, DVM, PhD, DACVS (Ithaca, NY), provides a scientific overview of adipose tissue and the microfat output obtained from the AutoPose™ system.

Orthobiologics

<p>Lisa A. Fortier, DVM, PhD, DACVS (Ithaca, NY), provides a scientific overview of adipose tissue and the microfat output obtained from the AutoPose™ system.</p>

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VID1-006390-en-US | A | Scientific Overview of Adipose Tissue From the AutoPose™ System

Lisa A. Fortier

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Scientific Overview of Adipose Tissue From the AutoPose™ System

I'm Lisa Fortier, professor of equine surgery at Cornell University. Today, I would like to present some of the science behind adipose tissue using the Arthrex adipose system. Adipose tissue is an additional conservative treatment option to provide cushioning and support to surrounding joint structures. Adipose tissue is a precursor to a wide spectrum of regenerative therapies. Due to its accessibility and abundant cellular content. The cellular content is comprised of stromal progenitors such as adipose derived mesenchymal stromal cells similar to mesenchymal stem cells, pericytes endothelial cells, and immunoregulatory cells, including blood cells. The term stromal vascular fraction, svf refers to the pelleted and cell component of adipose tissue, which is independent of the extracellular matrix and the adipocytes. This can be isolated via enzymatic or mechanical means. However, like cultured adipose derived MSCs, it is not FDA approved product. Alternatively, adipose can be resized into micronized fragmented adipose tissue or even further processed into nano fat. The first step in generating micro or nano fat is lipo aspiration. This is followed by rinsing and filtering to obtain the inject date and achieve a final and ideal sized output. There are very distinct and important differences in this processing method that have biological implications. In adipose, the niche environment is retained, which is important for retention, the biological activity of MSCs, and bioactive signals. Key differences in the generation of nano fat compared to micro fat using the adipose system is the inclusion of a fat emulsification step. You can see from these SEM images that adipose microstructure is retained in adipose while it is destroyed in nano fat. This has very important biological implications. In adipose, cellular viability is retained. However, the emulsification step in nano fat not only is the niche environment destroyed, but you can see in these calcein stained images very few viable cells remain in nano fat. This has been quantified by Yang and demonstrated to be a significant reduction in viable cells in nano fat compared to micro fat, this retention of cells is vital to the natural structural support that this cell phenotype provides. In addition to retain cellular viability, micro fat contains numerous anti-inflammatory and immunoregulatory growth factors, cytokines, and chemokines, as published by Greenwood. Rangi further showed that there is a release of paracrine factors that provide a robust biological backing behind this orthobiologics. On top of the structural support adipose tissue provides. In summary, adipose as a micro fragmented adipose tissue, provides viable cells, immunomodulatory molecules and offers a lot of potential in orthopaedic application as an addition to your Orthobiologics toolbox. This system is a closed system which decreases the chances of contamination, and adipose also is a syringe inside syringe technology, which allows for simplistic processing without complicated tubing that can be seen in other systems and processing can be completed in less than 30 minutes. Thank you for your time.

Scientific Overview of Adipose Tissue From the AutoPose™ System

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