Orthobiologics

Product

Products within the comprehensive line of AlloSync bone grafting solutions are derived from human allograft bone and maintain optimal osteoconductive potential. Demineralized bone graft products also have osteoinductive properties. The comprehensive portfolio includes a wide selection of advanced demineralized bone matrix (DBM) graft options:
- AlloSync Pure demineralized bone matrix
- AlloSync Expand demineralized cortical fibers
- AlloSync demineralized cancellous sponges and cortical fibers
- AlloSync putty, gel, and paste 
 

- AlloSync wedges
AlloSync products provide excellent handling characteristics and can be combined with bioactive fluids, such as platelet-rich plasma (PRP) or cPRP from bone marrow aspirate (BMA).

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AlloSync™ Bone Grafting Solutions

The AlloSync™ bone grafting solutions product line includes AlloSync Pure demineralized bone matrix and the AlloSync demineralized cancellous sponges and cortical fibers. These bone grafts are derived from 100% human allograft bone and can be hydrated with biologically active fluids.

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The unique long-strand geometry of AlloSync™ Expand 100% demineralized cortical fibers maximizes graft cohesion1 and provides a 3D interconnected matrix to promote cell migration across the bone void. AlloSync Expand fibers have demonstrated superior bone-forming capacity compared to standard particulate demineralized bone marrow.2 After hydration, the graft will expand to fill the void and create endplate-to-endplate contact in spinal fusion cases. AlloSync Expand fibers can be hydrated with biologic fluids, such as platelet-rich plasma or concentrated bone marrow aspirate.
References
1. Walsh WR, Lovric V, Russell N, Kim P, Larson MJ, Vizesi F, et al. Improved performance of SeaSpine demineralized bone fibers vs. three commercially available demineralized bone matrix products in an athymic rat posterolateral fusion model. IsoTis – Clinical Affairs. 2020.
2. Martin GJ, Boden SD, Titus L, Scarborough NL. New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis. Spine. 1999;24(7):637-645. doi:10.1097/00007632-199904010-00005.

AlloSync™ Expand Demineralized Cortical Fibers for Spinal Fusion Cases

Patrick A. Smith, MD (Columbia, MO), demonstrates a SpeedBridge™ rotator cuff repair augmented with interpositional AlloSync™ button (demineralized bone matrix) and Angel® system cPRP from BMA. He demonstrates using the Knotless SwiveLock® suture anchor, which has a tensionable knotless mechanism built into the eyelet that can be used to easily deliver the AlloSync button to the rotator cuff footprint.

SpeedBridge™ Rotator Cuff Repair With Knotless SwiveLock® Anchors and AlloSync™ Buttons

Chad D. Lavender, MD (Scott Depot, WV), demonstrates an all-inside ACL reconstruction augmented with bone marrow concentrate mixed with AlloSync™ Pure and autograft bone collected with the GraftNet™ device.

All-Inside ACL Reconstruction Using AlloSync™ Pure Implant and the GraftNet™ Device

Paul R. Fleissner, MD (Akron, OH), presents a case in which he performed a high tibial osteotomy (HTO) using a tibial opening wedge osteotomy plate. The osteotomy was augmented with AlloSync™ Pure demineralized bone matrix and Angel® concentrated platelet-rich plasma from bone marrow aspirate.

High Tibial Osteotomy Augmented With AlloSync™ Pure and Angel® cPRP From BMA

AlloSync™ Bone Grafts

Child (D)

ArthroCell™ and ArthroCell Plus bone grafts are osteogenic, osteoinductive, and osteoconductive—the three elements that are essential for bone formation. Both deliver a 100% human-derived product that mimics the structure of native bone, provides optimal handling, and resists irrigation. ArthroCell and ArthroCell Plus bone grafts use a novel DMSO-free cryoprotectant for preservation of cells, eliminating the need to rinse or decant during graft preparation. This viable bone matrix supports the bone remodeling process across a wide array of orthopedic and spinal applications.

ArthroCell™ and ArthroCell Plus™ Allografts - Viable Bone Matrices

ArthroCell™ bone allograft is a non‐immunogenic viable cellular bone allograft intended for use as bone void filler for a variety of bone defects, fusions, and nonunion orthopedic applications. It is cryopreserved for storage up to 2 years at −65°C.

ArthroCell™ Viable Cellular Bone Allograft

Thomas Temple, MD, (Miami, FL) and Christopher Adams, MD, (Arthrex® VP of Global Medical Education) discuss ArthroCell™ cellular bone graft and its uses in orthopedic applications.

ArthroCell™ Cellular Bone Grafts

Foot and Ankle

Nicholas W. Todd, DPM (Mountain View, CA), discusses a revision case for a failed 1st metatarsal phalangeal joint implant in which he used a cannulated revision bone dowel, ArthroCell™ viable bone matrix, and the MaxForce™ MTP fusion plate.

1st MTP Revision Using a Cannulated Revision Bone Dowel and Augmented With ArthroCell™ Viable Bone Matrix

Barth B. Riedel, MD (Loma Linda, CA), presents his treatment of nonunion distal radius fractures using Arthrex distal radius plates, augmented with ArthroCell™ viable cellular bone graft.

Distal Radius Malunions and Nonunions Augmented With ArthoCell™ Viable Cellular Bone Graft

ArthroCell™ Bone Allograft

Revision Bone Dowels offer surgeons a quick and effective solution for filling bone tunnels during staged ACL/PCL revision cases. The use of bone dowels provides an immediate structural and biologic architecture for stability and incorporation. Soaking the dowels in PRP or bone marrow concentrate provides an infusion of growth factors and cells to assist with the incorporation of the scaffold.
The Revision Bone Dowels were treated with the Allowash XG®* process to remove blood and bone marrow elements from the scaffold. The dowels are then preshaped with a tapered tip and cannulated for easier implantation. Treatment with Preservon®* technology allows for the Revision Bone Dowels to be stored in a prehydrated state for up to 5 years.
*Allowash XG and Preservon are a registered trademark of LifeNet Health.

Bone Dowel Revision Kit

Cannulated Revision Bone Dowels offer surgeons a quick and effective solution for filling the void left from a Cartiva®* implant, providing immediate structure and biologic architecture for stability and incorporation.
*Cartiva is a registered trademark of Wright Medical Group N.V.

Allograft Bone

AlloSync™ Bone Grafts

ArthroCell™ Bone Allograft

Cannulated Revision Bone Dowels