Name: ArthroCell™ Cellular Bone Allograft Matrix Overview
Uploaded: 2016-07-06T00:00:00Z
Channel: Arthrex

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VPT1-00644-EN | A | ArthroCell™ Cellular Bone Allograft Matrix Overview

Thomas Temple

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ArthroCell™ Cellular Bone Allograft Matrix Overview

My name is Thomas Temple. I'm a practicing orthopedic oncologist in Miami. I'm going to talk about a allogeneic cell matrix product. And specifically I'm going to talk about the matrix that we chose for this product and why we chose it. It's always been our belief at UTB that matrix drives tissue regeneration. We also believe that morphology alone can be inductive to have a perfect regenerative bone product. One needs osteoprogenitor cells, osteoinductive growth factors, and an osteoconductive matrix or scaffold. We chose a micro particulate graft for scientific reasons. We found that the micro particulates between 1 and 300 microns was most effective in forming early bone formation of adequate quality. The way we came about this conclusion was through a non-human primate study, where we created a defect in the medial femoral condyle of an adult male baboon. You could see the control on the left remains cystic, and we varied the particle sizes between 90 and 300 microns on the upper right, 53 and 75 microns on the lower left, and 500 to 800 microns on the lower right. We also looked at larger particle sizes in the course of this experiment. What we found grossly radiographically and microscopically, was that the 90 to 300 micron composite produced the best quality bone in the least amount of time. And if you could look on this nomogram, you'll see again that the 90 to 100 milligram micron composite was equivalent to autologous bone. This is just an example of the use of the matrix alone in this individual who had resection of a large aneurysmal bone cyst in the subtrochanteric hip with the application of a small amount of graft in the calcar region. We were able to regenerate bone in a very short period of time. That you could see on the slide in the lower right is quite significant and robust. So these particles placed in a defect and adjacent to bone formed bone in a rapid fashion. The particles themselves are highly conductive and result in brisk mesenchymal cell recruitment. The quality of bone formation is superior to the rate of healing is in fact accelerated. What's also important to note is heterotopic bone does not form in the soft tissues with this application.

ArthroCell™ Cellular Bone Allograft Matrix Overview

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